Methodology
How the model works
Autus isn't a tracker pretending to be science. Every compound carries a peer-reviewed pharmacokinetic (PK) profile, a citation trail, and a confidence rating you can audit. This page explains what's under the hood so you can decide how much to trust a given estimate.
Cited, not guessed
Every half-life, Cmax, and Tmax in Autus has a paper, a clinical trial, or a manufacturer datasheet behind it. Tap any value in the app to see its source — trial identifiers, PubMed IDs, and prescribing information are linked directly, so you're never taking a number on faith.
Each profile also carries a confidence rating reflecting how much primary evidence exists. A compound with multiple human trials rates higher than one extrapolated from animal data, and the app shows you which is which.
Two-compartment modeling
When you log a dose, Autus runs a real PK simulation rather than a simple decay curve. The model accounts for three phases:
- Absorption. How quickly the compound enters circulation from the injection or administration site.
- Distribution. How it spreads between the bloodstream and surrounding tissue compartments.
- Elimination. How it clears, driven by the compound's half-life and your dosing history.
The result is a projected blood-level curve with peak, trough, and time-in-range — so you can compare a 0.5 mg split against 1 mg once daily before you change a thing.
Your data, your model
Reference PK parameters are a starting point, not the final word. Autus calibrates against your own wearable signals — HRV, resting heart rate, sleep, and training load from Apple Health, Oura, Whoop, Garmin, and others. Two people on identical stacks see different curves, because their metabolism, sleep, and training are different.
Data sources & transparency
Profiles are sourced from published clinical trials, peer-reviewed pharmacology literature, and manufacturer prescribing information. Where the literature disagrees, we show the range rather than a single falsely-precise number. Questions about a specific compound's sourcing? Email hi@getautus.com — a human reads every message.